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Since the participation of GTPases in RBC health has only recently gained momentum, much remains to be studied about the roles and interactions of GTPases in response to stress stimuli and in various clinical conditions

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Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)